Induces susceptibility to atherosclerosis By similarity. Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM ａnd is required for efficient trafficking of PECAM1 to ａnd from the lateral border recycling compartment (LBRC) ａnd is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting ＇detachment＇ signals, ａnd changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell＇s active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals ａnd their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- ａnd hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).1) Brown S., Heinisch I., Ross E., Shaw K., Buckley C. D., Savill J. Nature 418:200-203 (2002) Bergom C., Paddock C., Gao C., Holyst T., Cell Sci. 121:1235-1242 (2008) Dasgupta B., Dufour E., Mamdouh Z., Muller W. A. J. Immunol. 182:5041-5051 (2009)
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CD31 (PECAM1) antibody was raised against a peptide sequence around aa.730~734 (R-T-E-G-S) derived from Human CD31 (PECAM1).

WB

Human