The NF-E2 DNA binding protein is composed of two subunits, p45 ａnd MafK. It regulates expression of globin genes in developing erythroid cells through interaction with Maf recognition elements (Mares). A family of NF-E2- related proteins, which are collectively known as the Cap ‘n’ collar (CNC) family ａnd include Nrf1 (also designated TCF11), Nrf2 ａnd Nrf3, are bZIP transcription factors that heterodimerize with Maf proteins to bind Mare sequences. The Nrf proteins also bind the antioxidant response element (ARE) ａnd are implicated in the regulation of detoxification enzymes ａnd the oxidative stress response. They do so by heterodimerizing with Jun family members (c-Jun, Jun B ａnd Jun D) to activate gene expression, specifically the detoxifying enzyme NQO1. Nrf2 is widely expressed ａnd is thought to translocate to the nucleus after treatment with xenobiotics ａnd antioxidants, which stimulate its release from its repressor protein, Keap1. The gene encoding human Nrf3 maps to chromosome 7p15.2. Nrf3 is highly expressed in placenta, B cells ａnd monocytes.
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Synthetic phospho-peptide corresponding to residues surrounding Ser40 of human Nrf2.

WBICC/IFIHCIPFC

Human