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技術(shù)文章

Nrf2 Catalog Number：OM638791

點擊次數(shù)：12 發(fā)布時間：2024/8/19 13:50:42
 

Product Profile

Product Name Nrf2
Antibody Type Primary Antibodies
Product description 
The Nrf2 antioxidant response pathway is "the primary cellular defense against the cytotoxic effects of oxidative stress." Among other effects, NFE2L2 increases the expression of several antioxidant enzymes. Several drugs that stimulate the NFE2L2 pathway are being studied for treatment of diseases that are caused by oxidative stress, ａnd dimethyl fumarate significantly reduced the progression of disability in multiple sclerosis. Under normal or unstressed conditions, Nrf2 is kept in the cylasm by a cluster of proteins that degrade it quickly. Under oxidative stress, Nrf2 is not degraded, but instead travels to the nucleus where it binds to a DNA promoter ａnd initiates transcription of antioxidative genes ａnd their proteins.
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Immunogen 
This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to Nrf2 aa 530-600.

Key Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

WBICC
 
WB:1:1000-1:2000
ICC:1:100
Species Reactivity

HumanMouseRat
Concentration 1 mg/mL.

Target Information

Alternative Names
erythroid derived 2 antibody HEBP1 antibody like 2 antibody NF E2 related factor 2 antibody NF-E2-related factor 2 antibody NF2L2_HUMAN antibody NFE2 related factor 2 antibody NFE2-related factor 2 antibody Nfe2l2 antibody Nrf 2 antibody NRF2 antibody Nuclear factor (erythroid derived 2) like 2 antibody Nuclear factor antibody nuclear factor erythroid 2 like 2 antibody Nuclear factor erythroid 2 related factor 2 antibody Nuclear factor erythroid 2-related factor 2 antibody Nuclear factor erythroid derived 2 like 2 antibody
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Molecular Weight(MW) 68 kDa
Cellular Localization Cylasm, Nucleus

Database Links

SwissProt ID Q16236

Application

  • Application

    Fig1: Western blot analysis on different lysates using anti-Nrf2 rabbit polyclonal antibodies.

  • Application

    Fig2: ICC staining Nrf2 in Hela cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Positive Control Raji, mouse liver, HepG2, Hela
Application Notes
WB:1:1000-1:2000
ICC:1:100

Additional Information

Form Liquid
Storage Instructions Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage Buffer 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
 

原創(chuàng)作者：上海篤瑪生物科技有限公司

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