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技術(shù)文章

PGC1 alpha+beta [JF09-71] Catalog Number：OM628310

點(diǎn)擊次數(shù)：23 發(fā)布時間：2024/8/16 11:30:37
 

Product Profile

Product Name PGC1 alpha+beta [JF09-71]
Antibody Type Primary Antibodies
Product description 
Transcription factors exert their effects by associating with co-activator or corepressor proteins. The co-activator complexes are thought to be constitutively active, requiring only proper positioning in the genome to initiate transcription. Co-activators include the steroid receptor coactivator (SRC) ａnd CREB binding protein (CBP) families that contain histone acetyltransferase (HAT) activity, which modifies chromatin structure. PPARgamma co-activator-1 (PGC-1) is a transcriptional cofactor of nuclear respiratory factor-1 (NRF-1), PPARbeta, PPARalpha ａnd other nuclear receptors that is induced by exposure to cold temperatures ａnd is involved in regulating thermogenic gene expression, protein uncoupling, ａnd mitochondrial biogenesis. PGC-1 has a low inherent transcriptional activity when it is not bound to a transcription factor. Docking of PGC-1 to PPARgamma stimulates an apparent conformational change that then enables PGC-1 to bind to ａnd assemble into complexes, which include the additional cofactors SRC-1 ａnd CBP/p300, ａnd results in a large increase in transcriptional activity.
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Immunogen 
recombinant protein

Key Feature

Clonality Monoclonal
Isotype IgG
Host Species Recombinant rabbit
Tested Applications

WB
 
WB:1:1,000
Species Reactivity

HumanMouseRat
Concentration 1 mg/mL.

Target Information

Alternative Names
LEM6 antibody Ligand effect modulator 6 antibody PERC antibody Peroxisome proliferative activated receptor
gamma
coactivator 1 alpha antibody Peroxisome proliferative activated receptor
gamma
coactivator 1 antibody Peroxisome proliferator activated receptor gamma coactivator 1 alpha antibody peroxisome proliferator-activated receptor gamma coactivator 1 beta antibody Peroxisome proliferator-activated receptor gamma coactivator 1-alpha antibody Peroxisome proliferator-activated receptor gamma coactivator 1-beta antibody peroxisome proliferator-activated receptor gamma
coactivator 1 beta antibody PGC 1 (alpha) antibody PGC 1 alpha antibody PGC 1v antibody PGC-1(beta) antibody PGC-1-alpha antibody PGC-1-beta antibody PGC-1-related estrogen receptor alpha coactivator antibody PGC1 antibody PGC1(alpha) antibody PGC1A antibody PGC1v antibody PPAR gamma coactivator 1 alpha antibody PPAR gamma coactivator 1 alpha 3 ligand effect modulator 6 antibody PPAR gamma coactivator 1 antibody PPAR gamma coactivator variant form antibody PPAR gamma coactivator-1beta antibody PPAR-gamma coactivator 1-alpha antibody PPAR-gamma coactivator 1-beta antibody PPARGC 1 alpha antibody PPARGC-1-alpha antibody PPARGC-1-beta antibody PPARGC1 antibody PPARGC1A antibody Ppargc1b antibody PRGC1_HUMAN antibody PRGC2_HUMAN antibody
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Molecular Weight(MW) 113 kDa
Cellular Localization Nucleus.

Database Links

SwissProt ID Q86YN6
Q9UBK2
415302
O70343
Q8VHJ7
Q811R2
Q9QYK2

Application

  • Application

    Fig1: Western blot analysis of PGC1 alpha+beta on different lysates using anti-PGC1 alpha+beta antibody at 1/1,000 dilution. Positive control: Lane 1: Mouse brain Lane 2: Mouse heart Lane 3: Mouse kidney

Positive Control Mouse heart tissue, mouse kidney tissue, mouse brain tissue.
Application Notes
WB:1:1,000

Additional Information

Form Liquid
Storage Instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage Buffer 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

原創(chuàng)作者：上海篤瑪生物科技有限公司

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