Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, ａnd tissue remodeling, as well as in disease processes, such as arthritis ａnd metastasis. Most MMP＇s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization ａnd the inflammatory response. Mutations in this gene have been associated with Winchester syndrome ａnd Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene.1) Beshir, A.B., et al. Cancer Lett. 299(2):137-149(2010)
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This MMP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 303-331 amino acids from the Central region of human MMP2.

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