Rabbit Polyclonal antibody to Caspase 1 alpha (caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase))This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large ａnd small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave ａnd activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, ａnd wound healing. This gene has been shown to induce cell apoptosis ａnd may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms. [provided by RefSeq]
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Recombinant protein encompassing a sequence within the center region of human Caspase 1. The exact sequence is proprietary.

ICC/IFIHC-PWB

Human