產(chǎn)品名稱淀粉樣體蛋白(amyloid precursor protein，APP)是一種廣泛存在于全身組織細胞上的單次跨膜蛋白，其經(jīng)蛋白酶裂解后會產(chǎn)生具有毒性作用的β-淀粉樣蛋白，迄為止人們對APP真正的生理功能仍知之甚少。

淀粉樣體蛋白(amyloid precursor protein，APP)是一種廣泛存在于全身組織細胞上的單次跨膜蛋白，因其經(jīng)蛋白酶裂解后產(chǎn)生具有毒性作用的β-淀粉樣蛋白(β-amyloid，Aβ)而廣受關注，但迄為止人們對APP真正的生理功能仍知之甚少，許多學者認為APP裂解后形成的Aβ沉積所形成的是AD的重要原因

查找：ANTI-AMYLOID PRECURSOR PROTEIN, PEPTIDE #3, #4, #5 ANTIBODY

Target Protein:
Amyloid Precursor Protein

IR:
Immunogen Range:381-480/770

Clonality:
Polyclonal

Isotype:
IgG

Entrez Gene:
351

Swiss Prot:
P05067

Source:
KLH conjugated synthetic peptide derived from of human APP:381-480/770

Purification:
affinity purified by Protein A

Storage:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 ａnd 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background:
This gene encodes a cell surface receptor ａnd transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted ａnd can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease ａnd cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Size:
50ul

Concentration:
1mg/ml

Applications:
WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100)
IF(1:100-500)

Cross Reactive Species:
Human
Mouse
Rat
Chicken
Dog
Pig
Cow
Horse
Rabbit
Sheep

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僅供科研使用。不能用于人和動物 等其它臨床診斷用！

原創(chuàng)作者：上海篤瑪生物科技有限公司