P28329 (Human)產(chǎn)品名稱
Anti-Myelin Basic蛋白抗體
參閱全部 Myelin Basic Protein 一抗
描述
兔多克隆抗體to Myelin Basic蛋白
宿主
Rabbit
特異性
This antibody is specific to myelin basic proteins. It may cross react with other isoforms of myelin basic proteins.
經(jīng)測(cè)試應(yīng)用
適用于: Sandwich ELISAmore details
種屬反應(yīng)性
與反應(yīng): Pig
預(yù)測(cè)可用于: Mammals
免疫原
Full length native protein (purified) corresponding to Cow Myelin Basic Protein.

常規(guī)說明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies ａnd knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

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查找：ANTI-MYELIN BASIC PROTEIN ANTIBODY

功能
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation ａnd stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, ａnd may also be involved in signaling pathways in T-cells ａnd neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
組織特異性
MBP isoforms are found in both the central ａnd the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen ａnd spinal cord, as well as in cell lines derived from the immune system.
疾病相關(guān)
Note=The reduction in the surface charge of citrullinated and/or methylated MBP could result in a weakened attachment to the myelin membrane. This mechanism could be operative in demyelinating diseases such as chronical multiple sclerosis (MS), ａnd fulminating MS (Marburg disease).
序列相似性
Belongs to the myelin basic protein family.
發(fā)展階段
Expression begins abruptly in 14-16 week old fetuses. Even smaller isoforms seem to be produced during embryogenesis; some of these persisting in the adult. Isoform 4 expression is more evident at 16 weeks ａnd its relative proportion declines thereafter.
翻譯后修飾
Several charge isomers of MBP; C1 (the most cationic, least modified, ａnd most abundant form), C2, C3, C4, C5, C6, C7, C8-A ａnd C8-B (the least cationic form); are produced as a result of optional PTM, such as phosphorylation, deamidation of glutamine or asparagine, arginine citrullination ａnd methylation. C8-A ａnd C8-B contain each two mass isoforms termed C8-A(H), C8-A(L), C8-B(H) ａnd C8-B(L), (H) standing for higher ａnd (L) for lower molecular weight. C3, C4 ａnd C5 are phosphorylated. The ratio of methylated arginine residues decreases during aging, making the protein more cationic.
The N-terminal alanine is acetylated (isoform 3, isoform 4, isoform 5 ａnd isoform 6).
Arg-241 was found to be 6% monomethylated ａnd 60% symmetrically dimethylated.

原創(chuàng)作者：上海篤瑪生物科技有限公司