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查找：Anti-Tyrosine Hydroxylase Antibody

點擊次數(shù)：17 發(fā)布時間：2024/1/17 11:09:25
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查找：Anti-Tyrosine Hydroxylase Antibody


描述
Tyrosine Hydroxylase Antibody is a non-conjugated ａnd Rabbit origined monoclonal antibody about 59 kDa, targeting to Tyrosine Hydroxylase. It can be used for WB,ICC,IHC-P,FC,IF assays with tag free, in the background of Human, Mouse, Rat.

標(biāo)簽
Free

分子量
Predicted band size: 59 kDa

純度
Protein A affinity purified.

亞細胞定位
Cylasm.

偶聯(lián)
Non-conjugated

研究域
Neuroscience

產(chǎn)品類別
Primary Antibody; Rabbit Monoclonal Antibody

宿主
Rabbit

反應(yīng)物種
Human, Mouse, Rat

蛋白數(shù)據(jù)庫
SwissProt: P07101 Human;SwissProt: P24529 Mouse;SwissProt: P04177 Rat

推薦稀釋比例
WB: 1:1,000-1:10,000 ;ICC: 1:50-1:200 ;IHC-P: 1:2,000 ;FC: 1:50-1:100 ;IF: 1:200

應(yīng)用
WB, ICC, IHC-P, FC, IF

性狀
液體

組分
Supplied in 1*TBS (pH7.4), 0.05% BSA ａnd 40% Glycerol. Preservative: 0.05% Sodium Azide.

保存條件 & 期限
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

運輸條件
Shipping with blue ice.

同型
IgG

免疫原
Synthetic peptide corresponding to Human Tyrosine Hydroxylase.The exact sequence is proprietary to MCE.

查找：Anti-Tyrosine Hydroxylase Antibody

 

功能
Plays an important role in the physiology of adrenergic neurons.
組織特異性
Mainly expressed in the brain ａnd adrenal glands.
通路
Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2.
疾病相關(guān)
Defects in TH are the cause of dystonia DOPA-responsive autosomal recessive (ARDRD) [MIM:605407]; also known as autosomal recessive Segawa syndrome. ARDRD is a form of DOPA-responsive dystonia presenting in infancy or early childhood. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Some cases of ARDRD present with parkinsonian symptoms in infancy. Unlike all other forms of dystonia, it is an eminently treatable condition, due to a favorable response to L-DOPA.
Note=May play a role in the pathogenesis of Parkinson disease (PD). A genome-wide copy number variation analysis has identified a 34 kilobase deletion over the TH gene in a PD patient but not in any controls.
序列相似性
Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
Target information above from: UniProt accession P07101
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
 

 

 

原創(chuàng)作者：上海篤瑪生物科技有限公司

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