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技術文章
查找：Anti-PSD95 (phospho S418)抗體[EPR2618Y]
點擊次數：27 發(fā)布時間：2024/1/15 14:03:05
Anti-PSD95 (phospho S418)抗體[EPR2618Y]
| 重組ANTI-PSD95 (PHOSPHO S418)抗體[EPR2618Y] |
| Anti-PSD95 (phospho S418)抗體[EPR2618Y] |
| 抗PSD95（磷酸S418）抗體[EPR2618Y] |
| 279.3154 |
| 背景： | Postsynaptic Density protein 95 (PSD95) belongs to the membrane-associated guanylate kinase (MAGUK) family. PSD contains receptors with associated signaling- ａnd scaffolding-proteins that organize signal-transduction pathways near the post-synaptic membrane (2). As a scaffolding protein, PSD95 controls of receptor trafficking during synaptic plasticity by anchoring synaptic proteins. PSD95 is necessary in synaptic plasticity associated with NMDA receptor signaling (1). After hetermultimerization with DLG2, PSD95 associates with cylasmic tail of NMDA receptor subunit ａnd potassium channel clusters. PSD95 has been linked to autism, drug addiction, learning ａnd memory, with its phosphorylation being critical for regulation of its function (3).REFERENCES1. El-Husseini AE. et al. Science 17:1364-1368-416, 2004.2. Yamauchi T, et al. MSR 21(4):266-286, 2003.3. Kim MJ, et al. Neuron 56: 488-502, 2007. |
| 其他名字： | DLG4, PSD95, Disks large homolog 4, Synapse-associated protein 90 |
| 克隆名： | EPR2618Y |
靶點信息
| 基因id： | 1742 |
| 蛋白名： | DLG4 |
| 胞內定位： | Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note=High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells |
| 同義詞： | PSD95 |
應用與保存
| 稀釋濃度： | WB~~1:500 |
| 注意事項： | PSD95 Antibody Phospho (pS418) is for research use only ａnd not for use in diagnostic or therapeutic procedures. |
其他
| 參考文獻： | 1. El-Husseini AE. et al. Science 17:1364-1368-416, 2004.2. Yamauchi T, et al. MSR 21(4):266-286, 2003.3. Kim MJ, et al. Neuron 56: 488-502, 2007. |
| 保存條件： | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| 標記物： | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide ａnd 0.05% BSA. |
| 主要序列號： | P78352 |
| 分子量： | 80495 Da |
| 功能： | Interacts with the cylasmic tail of NMDA receptor subunits ａnd shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity). |
Anti-PSD95 (phospho S418)抗體[EPR2618Y]
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