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科學(xué)大講堂 | 信號(hào)通路專題系列一：Nf-κB信號(hào)通路
點(diǎn)擊次數(shù)：741 發(fā)布時(shí)間：2018/12/11
Transcriptional programs regulated by Nf-κB are essential to the development ａnd maintenance of the immune system, skeletal system ａnd epithelium. In these settings, Nf-κB contributes to the control of cell survival, differentiation ａnd proliferation. Aberrant activation of Nf-κB has been associated with numerous diseases such as cancer, autoimmune disease, neurodegenerative diseases ａnd cardiovascular disease. The Nf-κB signaling pathway is most characterized ａnd well understood in its role in chronic inflammation ａnd auto-immune disease.
Nf-κB調(diào)控的轉(zhuǎn)錄程序?qū)γ庖呦到y(tǒng)，骨骼系統(tǒng)和上皮細(xì)胞的發(fā)育和維持至關(guān)重要。在這些環(huán)境中，Nf-κB有助于控制細(xì)胞存活，分化和增殖。 Nf-κB異�；罨c許多疾病有關(guān)，如癌癥，自身免疫性疾病，神經(jīng)退行性疾病和心血管疾病。Nf-κB信號(hào)傳導(dǎo)途徑在慢性炎癥和自身免疫疾病中的作用*具特征并且很好理解。
Nf-κB調(diào)控的轉(zhuǎn)錄程序?qū)γ庖呦到y(tǒng)，骨骼系統(tǒng)和上皮細(xì)胞的發(fā)育和維持至關(guān)重要。在這些環(huán)境中，Nf-κB有助于控制細(xì)胞存活，分化和增殖。 Nf-κB異�；罨c許多疾病有關(guān)，如癌癥，自身免疫性疾病，神經(jīng)退行性疾病和心血管疾病。Nf-κB信號(hào)傳導(dǎo)途徑在慢性炎癥和自身免疫疾病中的作用*具特征并且很好理解。
Nf-κB proteins are characterized by the presence of a 300-amino acid sequence on the N-terminus called the Rel homology domain (RHD). Five members comprise the Nf-κB protein family: RelA/p65, RelB, c-Rel, p50 ａnd p52. These proteins bind to kB sites as homo- or hetero- dimers which can have a positive or negative impact on gene transcription.
There are two types of Nf-κB signaling pathway: canonical ａnd non-canonical. Both require activation through post translational modifications of IkB inhibitors. Canonical pathway activation predominantly occurs through BCR, TCR, TLR4, IL-1R or TNF-R receptors, whereas the non-canonical pathway involves receptor activation of CD40L, BAFF or lymphotoxin-B.
Nf-κB蛋白質(zhì)的特征在于在N-末端存在稱為Rel同源性結(jié)構(gòu)域（RHD）的300個(gè)氨基酸的序列。Nf-κB蛋白家族由五個(gè)成員組成：RelA / p65，RelB，c-Rel，p50和p52。這些蛋白作為同源或異源二聚體結(jié)合到kB位點(diǎn)上，可能對(duì)基因轉(zhuǎn)錄產(chǎn)生正面的或負(fù)面的影響。
Nf-κB信號(hào)傳導(dǎo)途徑有兩種類型：典型和非典型。兩者都需要通過(guò)IkB抑制劑的翻譯后修飾來(lái)激活。典型途徑活化主要通過(guò)BCR，TCR，TLR4，IL-1R或TNF-R受體發(fā)生，而非經(jīng)典途徑涉及CD40L，BAFF或淋巴毒素-B的受體活化。
There are two types of Nf-κB signaling pathway: canonical ａnd non-canonical. Both require activation through post translational modifications of IkB inhibitors. Canonical pathway activation predominantly occurs through BCR, TCR, TLR4, IL-1R or TNF-R receptors, whereas the non-canonical pathway involves receptor activation of CD40L, BAFF or lymphotoxin-B.
Nf-κB蛋白質(zhì)的特征在于在N-末端存在稱為Rel同源性結(jié)構(gòu)域（RHD）的300個(gè)氨基酸的序列。Nf-κB蛋白家族由五個(gè)成員組成：RelA / p65，RelB，c-Rel，p50和p52。這些蛋白作為同源或異源二聚體結(jié)合到kB位點(diǎn)上，可能對(duì)基因轉(zhuǎn)錄產(chǎn)生正面的或負(fù)面的影響。
Nf-κB信號(hào)傳導(dǎo)途徑有兩種類型：典型和非典型。兩者都需要通過(guò)IkB抑制劑的翻譯后修飾來(lái)激活。典型途徑活化主要通過(guò)BCR，TCR，TLR4，IL-1R或TNF-R受體發(fā)生，而非經(jīng)典途徑涉及CD40L，BAFF或淋巴毒素-B的受體活化。
Helping your research
Biorbyt has an extensive range of small molecules available as research reagents to target proteins in the NF-κB pathway. We provide the best service ａnd a simple buying process allowing you to focus on your valuable research. Take a look at our product pages where you will find competitive pricing, lead times, ａnd easy delivery options. If you have any questions, just ask us.
Biorbyt擁有廣泛的小分子，可用作研究試劑以靶向NF-κB通路中的蛋白質(zhì)。我們提供的服務(wù)和簡(jiǎn)單的購(gòu)買流程，讓您專注于您的寶貴研究�？纯次覀兊漠a(chǎn)品頁(yè)面，您可以找到具有競(jìng)爭(zhēng)力的價(jià)格，交貨期和易于交付的選項(xiàng)。如果您有任何問(wèn)題，請(qǐng)聯(lián)系我們。
Nf-κB信號(hào)通路相關(guān)抗體推薦：
Biorbyt擁有廣泛的小分子，可用作研究試劑以靶向NF-κB通路中的蛋白質(zhì)。我們提供的服務(wù)和簡(jiǎn)單的購(gòu)買流程，讓您專注于您的寶貴研究�？纯次覀兊漠a(chǎn)品頁(yè)面，您可以找到具有競(jìng)爭(zhēng)力的價(jià)格，交貨期和易于交付的選項(xiàng)。如果您有任何問(wèn)題，請(qǐng)聯(lián)系我們。
Nf-κB信號(hào)通路相關(guān)抗體推薦：
