15-HETE由花生四烯酸（AA）通過(guò)15-脂氧合酶（LOX）活性形成（1）。已經(jīng)表明-HETE參與多種病理狀況，包括癌癥（2）、高血壓（3）、過(guò)敏性鼻炎（4）和關(guān)節(jié)炎（5）。有趣的是，15-LOX還產(chǎn)生脂毒素A4和B4。也可以使用這種15（S）-HETE ELISA用于15-LOX活性的測(cè)量。

這種競(jìng)爭(zhēng)性ELISA可用于多達(dá)24個(gè)樣品的一式三份分析，并包含一個(gè)96孔板，一個(gè)小瓶15-HETE標(biāo)準(zhǔn)品、一小瓶15-HETE-綴合的HRP以及用于樣品和HRP稀釋液的緩沖液，以及洗盤子。

Detroit R&D 15-HETE高血壓/癌癥ELISA試劑盒相關(guān)研究： 

12-HETE 高血壓酶聯(lián)免疫功能試劑盒

Detroit R&D15-HETE高血壓/癌癥ELISA試劑盒引用文獻(xiàn)：

1. Dobrian AD, Lieb DC, Cole BK, Taylor-Fishwick DA,Chakrabarti SK, Nadler JL. Functional ａnd pathological roles of the 12- ａnd 15-lipoxygenases. Progress in Lipid Research (2011) 50, 115-131 ａnd references therein.

2. Pidgeon GP, Lysaght J, Krishnamoorthy S, Reynolds JV,O＇Byrne K, Nie D, Honn KV. Lipoxygenase metabolism:roles in tumor progression ａnd survival. Cancer Metastasis Rev (2007) 26, 503–524 ａnd references therein.

3. M.D. Mitchell ａnd J.M. Koenig.  Increased production of 15-hydroxyeicosatetraenoic acid by placentae from pregnancies complicated by pregnancy-induced hypertension

4. Ramis I, Catafau JR, Serra J, Bulbena O, Picado C, Gelpi E. In vivo release of 15-HETE ａnd other arachidonic acid metabolites in nasal secretions during early allergic reactions. Prostaglandins (1991) 42(5):411-20

5. Fogh, K., et. al. 15-Hydroxy-eicosatetraenoic acid (15-Hete) inhibits carragheenan-induced experimental arthritis ａnd reduces synovial fluid leukotriene B4 (LTB4). (1989) Prostaglandins 37: 213-228

Detroit R&D注于心血管疾病、癌癥的研究，診斷和治療域。涉及環(huán)境健康科學(xué)、高血壓、乳腺癌和列腺癌相關(guān)研究域。艾美捷科技是Detroit R&D的中國(guó)代理商，為科研工作者提供優(yōu)質(zhì)的產(chǎn)品與服務(wù)。

來(lái)源：https://www.amyjet.com/news/Detroit-R-D-new.shtml