脂肪酸結(jié)合蛋白6（FABP6）是細(xì)胞內(nèi)脂質(zhì)結(jié)合蛋白（iLBP）家族的一員，在膽汁酸穩(wěn)態(tài)中發(fā)揮作用。它由10條反平行的β鏈組成，形成含有脂質(zhì)結(jié)合位點(diǎn)的β桶，主要在回腸的腸上皮細(xì)胞中表達(dá)，FABP6結(jié)合膽汁酸和脂肪酸，并與回腸膽汁酸轉(zhuǎn)運(yùn)蛋白相互作用，以幫助膽汁酸吸收，促進(jìn)膽汁酸的細(xì)胞內(nèi)運(yùn)輸，大腸癌患者血清FABP6水平升高，手術(shù)切除癌組織后降低。FABP6T79M與肥胖個(gè)體2型糖尿病風(fēng)險(xiǎn)降低相關(guān)。

Cayman ChemicalFABP6兔單克隆抗體（克隆201）可用于流式細(xì)胞術(shù)（FC），免疫細(xì)胞化學(xué)（ICC）和免疫熒光（IF）應(yīng)用。

Cayman Chemical艾美捷FABP6兔單克隆抗體技術(shù)參數(shù)：

同義詞：脂肪酸結(jié)合蛋白6、腸膽汁酸結(jié)合蛋白

免疫原：重組人FABP6

配方：50或100µl蛋白A親和純化單克隆抗體

宿主：兔子

同種型：IgG抗體

應(yīng)用：FC，ICC，IF

存儲：-80℃

穩(wěn)定性：≥1年

Cayman Chemical艾美捷FABP6兔單克隆抗體相關(guān)文獻(xiàn)：

1. Smathers, R.L., ａnd Petersen, D.R. The human fatty acid-binding protein family: Evolutionary divergences ａnd functions. Hum. Genomics 5(3), 170-191 (2011).

2. Hendrick, A.G., Müller, I., Willems, H., et al. Identification ａnd investigation of novel binding fragments in the fatty acid binding protein 6 (FABP6). J. Med. Chem. 59(17), 8094-8102 (2016).

3. Storch, J., ａnd McDermott, L. Structural ａnd functional analysis of fatty acid-binding proteins. J. Lipid Res. 50 Suppl(Suppl), S126-S131 (2009).

4. Kim, K., Cistola, D.P., ａnd Frieden, C. Intestinal fatty acid-binding protein: The structure ａnd stability of a helix-less variant. Biochemistry 35(23), 7553-7558 (1996).

5. Habib, S.M., Zwicker, B.L., Wykes, L., et al. Sexually dimorphic response of mice to the Western-style diet caused by deficiency of fatty acid binding protein 6 (Fabp6). Physiol. Rep. 9(3), e14733 (2021).

6. Zhang, Y., Zhao, X., Deng, L., et al. High expression of FABP4 ａnd FABP6 in patients with colorectal cancer. World J. Surg. Oncol. 17(1), 171 (2019).

7. Fisher, E., Grallert, H., Klapper, M., et al. Evidence for the Thr79Met polymorphism of the ileal fatty acid binding protein (FABP6) to be associated with type 2 diabetes in obese individuals. Mol. Genet. Metab. 98(4), 400-405 (2009).

Cayman Chemical涉及癌癥、腫瘤、氧化損傷、凋亡、氧化性損傷、代謝、內(nèi)分泌學(xué)等多種研究域。艾美捷科技是Cayman Chemical的中國代理商，為科研工作者提供優(yōu)質(zhì)的產(chǎn)品與服務(wù)。

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