Advanced Targeting Systems/ATSbio艾美捷192 IgG SAP是小鼠抗大鼠p75NTR單克隆抗體和核糖體失活蛋白saporin的化學(xué)綴合物。它特別地消除了表達(dá)p75NTR的細(xì)胞，也被稱為低親和力神經(jīng)生長因子受體。

Advanced Targeting Systems/ATSbio 艾美捷其它高引文數(shù)量研究：

IT-14 CTB-SAP 靶向表達(dá)GM1受體的細(xì)胞

IT-16 mu p75-SAP 靶向表達(dá)小鼠p75NTR的細(xì)胞

IT-03 Anti-DBH-SAP 靶向表達(dá)大鼠多巴胺β羥化酶的細(xì)胞

IT-10 IB4-SAP 靶向表達(dá)α-D-吡喃半乳糖苷殘基的細(xì)胞

Advanced Targeting Systems/ATSbio艾美捷192 IgG SAP相關(guān)文獻(xiàn)：

Neurotoxic effects, mechanisms, ａnd outcome of 192 IgG-Saporin lesions.

Petrosini L, De Bartolo P, Cutuli D (2021) Neurotoxic effects, mechanisms, ａnd outcome of 192 IgG-Saporin lesions. RM Kostrzewa (Ed.): Handbook of Neurotoxicity . Springer, Cham doi: 10.1007/978-3-030-71519-9_79-1

Summary: 192-IgG-saporin selectively destroys basal forebrain cholinergic neurons that provide cholinergic input to the hippocampus, entire cortical mantle, amygdala, ａnd olfactory bulb. Immunotoxic lesions by 192-IgG-saporin represent a valid animal model of Alzheimer’s disease, given the degeneration of basal cholinergic system present in this pathology. The selective lesioning of cholinergic innervation by means of 192-IgG-saporin (injected i.p. or i.c.v.) is able to interfere with experience-dependent plasticity.

Related Products: 192-IgG-SAP (Cat. #IT-01)

Pain sensitivity following loss of cholinergic basal forebrain (CBF) neurons in the rat.

Vierck C, Yezierski R, Wiley R (2016) Pain sensitivity following loss of cholinergic basal forebrain (CBF) neurons in the rat. Neuroscience 319:23-34. doi: 10.1016/j.neuroscience.2016.01.038

Objective: There is a large amount of research on the involvement of cholinergic mechanisms on spinal transmission of pain signals, indicating that cholinergic agonists can attenuate this kind of pain. In contrast, some studies have shown affective reactions to pain are suppressed by cholinergic antagonists. The authors investigated the disagreement between reflexive ａnd affective reactions.

Summary: Lesioned rats displayed decreased escape from thermal stimulation, as well as loss of the normal hyperalgesic effect of sound stress. Results indicate that the basal forebrain cholinergic system plays a role in central processing of pain.

Usage: Administration of 192-IgG-SAP with a 4-μg injection into the left lateral ventricle of rats. Animals were tested in temperature escape ａnd sound stress models.

Related Products: 192-IgG-SAP (Cat. #IT-01)

Advanced Targeting Systems(ATSbio)主要研究域包含神經(jīng)靶向毒素，神經(jīng)生物學(xué)研究方面的抗體/蛋白，靶向劑內(nèi)化水平檢測工具等。艾美捷科技是ATSbio的中國代理商，為科研工作者提供優(yōu)質(zhì)的產(chǎn)品與服務(wù)。

來源：https://www.amyjet.com/brand/Advanced-Targeting-Systems.shtml