艾美捷TRC a，a-二甲基-4-化學(xué)性質(zhì)：

Catalogue NumberD474700

Chemical Namea,a-Dimethyl-4-[(methylamino)methyl]-2-thiazolemethanol Hydrochloride

Alternate CAS #Free Base: 1051463-24-1

Molecular FormulaC₈H₁₅ClN₂OS

AppearanceDark Brown Gel to Light Brown Solid

Molecular Weight222.74

Storage-20°C, Inert atmosphere, Light sensitive

SolubilityChloroform, DMSO, Methanol

CategoryStandards; Pharmaceutical/API Drug Impurities/Metabolites;

ApplicationsA Cobicistat (C633150) impurity. Cobicistat is a HIV protease inhibitor ａnd have been coadministered with low-dose ritonavir (R535000) as a pharmacoenhancer, significantly increasing their plasma concentrations.

ReferencesVon, H., Exp. Rev. Clin. Pharmacol., 5, 557 (2012); Lepist, E.I., et al.: Antimicrob. Agent. Chemother., 56, 5409 (2012); Orr, S.T.M., et al.: J. Med. Chem., 55, 4896 (2012);

目錄編號(hào)D474700

化學(xué)名稱a，a-二甲基-4-[（甲氨基）甲基]-2-噻唑甲醇鹽酸鹽

備用CAS自由基：1051463-24-1

分子式C₈H₁₅ClN公司₂操作系統(tǒng)

外觀深棕色凝膠至淺棕色固體

分子量222.74

儲(chǔ)存-20°C，惰性氣氛，光敏

溶解度氯丨仿、DMSO、甲醇

類別標(biāo)準(zhǔn)；藥物/原料藥藥物雜質(zhì)/代謝物；

參考文獻(xiàn)Von，H.，Exp.Rev.Clin。藥理學(xué)。，5, 557 (2012); Lepist，E.I.等人：抗微生物。代理人Chemother。，56, 5409 (2012); Orr，S.T.M.等人：《醫(yī)學(xué)化學(xué)雜志》。，55, 4896 (2012);

艾美捷TRC a，a-二甲基-4-相關(guān)研究：

(2＇S)-Nicotine 1-Oxide-d4

rac-Nicotine 1-Oxide-d4

1,1-Dimethyl-4-phenylpiperazinium Iodide

1,3-Dioleoylglycerol-d5

Diphenyl Terephthalate

2,4-Dichloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine

Dimethyl 2,2＇-((2-(2-(2-(Bis(2-methoxy-2-oxoethyl)amino)-5-(chlorocarbonyl)phenoxy)ethoxy)-4-methylphenyl)azanediyl)diacetate

2-(2,4-Dichlorophenyl)thiazole-4-carboxylic Acid

4,5-Dimethylnicotinonitrile

2,5-Dichloro-4-methylpyrimidine

TRC擁有多域的化學(xué)業(yè)技術(shù)，包括碳水化合物，芳香烴，硝化物，硫化物以及放射同位素和穩(wěn)定同位素標(biāo)記化合物，各類標(biāo)準(zhǔn)品等。艾美捷科技是TRC的中國(guó)代理商，為科研工作者提供優(yōu)質(zhì)的產(chǎn)品與服務(wù)。

來(lái)源：https://www.amyjet.com/brand/Toronto-Research-Chemicals.shtml